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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK4
All Species:
4.55
Human Site:
S581
Identified Species:
9.09
UniProt:
P51957
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51957
NP_003148.2
841
94597
S581
V
G
K
V
D
V
T
S
T
Q
K
E
A
E
N
Chimpanzee
Pan troglodytes
XP_516519
889
99702
S655
S
R
S
S
E
M
S
S
S
K
D
R
P
L
S
Rhesus Macaque
Macaca mulatta
XP_001082793
1258
142958
L892
S
L
K
L
E
G
N
L
E
E
P
D
D
L
E
Dog
Lupus familis
XP_533795
879
98359
L620
A
G
K
K
D
V
T
L
T
Q
K
D
A
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1J2
792
88976
L557
A
S
A
K
D
R
P
L
S
A
R
E
R
R
R
Rat
Rattus norvegicus
NP_001013152
793
89178
L559
A
S
S
K
D
R
P
L
S
A
R
E
R
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521008
756
85471
W523
A
S
S
K
L
G
I
W
H
H
D
R
P
L
S
Chicken
Gallus gallus
XP_414252
807
90823
H556
A
Q
S
C
A
E
E
H
I
A
K
M
S
V
S
Frog
Xenopus laevis
Q7ZZC8
944
104521
P668
N
G
R
L
A
M
T
P
N
E
R
P
Q
G
S
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
A464
C
G
A
S
H
V
L
A
V
T
N
E
R
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SLI2
612
68818
T379
T
S
R
R
I
M
E
T
G
R
R
S
D
H
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P48479
858
94329
S610
R
S
A
P
S
A
P
S
L
R
D
R
K
P
S
Conservation
Percent
Protein Identity:
100
88.4
25.5
73
N.A.
72.2
72.4
N.A.
57
58.8
21
25.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
88.6
42.5
80.1
N.A.
80.5
79.7
N.A.
68
71.6
37.7
43.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
73.3
N.A.
13.3
13.3
N.A.
0
6.6
13.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
46.6
33.3
80
N.A.
26.6
26.6
N.A.
6.6
20
53.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.6
N.A.
20.9
Protein Similarity:
N.A.
N.A.
N.A.
44.3
N.A.
39.2
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
42
0
25
0
17
9
0
9
0
25
0
0
17
0
0
% A
% Cys:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
34
0
0
0
0
0
25
17
17
0
0
% D
% Glu:
0
0
0
0
17
9
17
0
9
17
0
34
0
25
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
34
0
0
0
17
0
0
9
0
0
0
0
9
0
% G
% His:
0
0
0
0
9
0
0
9
9
9
0
0
0
9
0
% H
% Ile:
0
0
0
0
9
0
9
0
9
0
0
0
0
0
0
% I
% Lys:
0
0
25
34
0
0
0
0
0
9
25
0
9
0
0
% K
% Leu:
0
9
0
17
9
0
9
34
9
0
0
0
0
25
9
% L
% Met:
0
0
0
0
0
25
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
0
0
0
0
0
9
0
9
0
9
0
0
0
17
% N
% Pro:
0
0
0
9
0
0
25
9
0
0
9
9
17
9
0
% P
% Gln:
0
9
0
0
0
0
0
0
0
17
0
0
9
0
0
% Q
% Arg:
9
9
17
9
0
17
0
0
0
17
34
25
25
17
17
% R
% Ser:
17
42
34
17
9
0
9
25
25
0
0
9
9
0
42
% S
% Thr:
9
0
0
0
0
0
25
9
17
9
0
0
0
0
0
% T
% Val:
9
0
0
9
0
25
0
0
9
0
0
0
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _